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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ricardo Pérez | 1.858 | 2022-2039 | |
| 2 | José Gómez | 2.229 | 2024-2039 | |
| 3 | Bill Gallagher | 2.378 | 2017-2033 | |
| 4 | Bob Burns# | 2.447 | 2023-2040 | |
| 5 | Gustavo Hernández# | 2.463 | 2029-2040 | |
| 6 | Matt Brown# | 2.508 | 2025-2040 | |
| 7 | Adrian Peterson | 2.524 | 2015-2027 | |
| 8 | Chris York* | 2.583 | 2012-2028 | |
| 9 | Conan McCullough* | 2.630 | 2007-2018 | |
| 10 | Enrique Vázquez* | 2.640 | 2024-2037 | |
| 11 | Víctor Matos | 2.642 | 2007-2016 | |
| 12 | Edgardo Trevino# | 2.659 | 2033-2040 | |
| 13 | Markus Hancock* | 2.661 | 2008-2026 | |
| 14 | Bryant Burris | 2.707 | 2011-2025 | |
| 15 | Alfredo Aranda | 2.746 | 2016-2036 | |
| 16 | Raúl Cruz# | 2.803 | 2035-2040 | |
| 17 | Luppe van Dam# | 2.819 | 2029-2040 | |
| 18 | Manuel Pacheco | 2.828 | 2021-2034 | |
| 19 | Jim Ratzlaff | 2.851 | 2014-2030 | |
| 20 | Randy Smith* | 2.872 | 2016-2032 | |
| 21 | Gunner MacGruder* | 2.927 | 2014-2029 | |
| 22 | Brian Clark# | 2.931 | 2032-2040 | |
| 23 | José Ojeda# | 2.947 | 2035-2040 | |
| 23 | Motoyuki Hatsutori | 2.947 | 2024-2033 | |
| 23 | Michel Provost* | 2.947 | 2016-2030 | |
| 26 | Yakamochi Suitani* | 2.949 | 2021-2034 | |
| 27 | Jorge Castillo# | 2.955 | 2026-2040 | |
| 28 | Juan Acosta# | 2.963 | 2029-2040 | |
| 29 | Manuel Corona* | 2.994 | 2012-2028 | |
| 30 | Raúl Cruz | 2.995 | 2016-2032 | |
| 31 | Jeffrey Mendoza# | 3.022 | 2028-2040 | |
| 32 | Ángel Valdéz | 3.023 | 2027-2037 | |
| 33 | Fred Womack | 3.043 | 2025-2035 | |
| 34 | Manuel Gonzáles# | 3.051 | 2029-2039 | |
| 35 | Roberto Rivera# | 3.058 | 2032-2040 | |
| 36 | Neil Maes | 3.072 | 2019-2032 | |
| 37 | Kensaku Gato | 3.079 | 2021-2037 | |
| 38 | Glenn Thomas | 3.089 | 2024-2037 | |
| 39 | David Chesney | 3.090 | 2013-2028 | |
| 40 | Edgardo Guerra | 3.100 | 2026-2036 | |
| 40 | Bryan Stewart | 3.100 | 2007-2015 | |
| 42 | Keitaro Kodo | 3.110 | 2012-2017 | |
| 43 | José Trejo | 3.115 | 2026-2036 | |
| 44 | Julián Thomas | 3.123 | 2017-2028 | |
| 45 | Félix Maese | 3.135 | 2014-2027 | |
| 46 | Eric Elliott | 3.138 | 2025-2038 | |
| 47 | Kijuro Kojima | 3.143 | 2007-2015 | |
| 48 | Luis Mora | 3.144 | 2007-2022 | |
| 49 | Owen Barse# | 3.148 | 2030-2040 | |
| 50 | Dan Boorman | 3.156 | 2023-2038 | |
| 51 | Miguel Cantú | 3.165 | 2015-2028 | |
| 52 | Daniel Hernández# | 3.169 | 2032-2040 | |
| 53 | Bartolo García | 3.170 | 2025-2035 | |
| 54 | Bang-xao Niu# | 3.174 | 2031-2040 | |
| 55 | Nelson Anderson | 3.181 | 2007-2017 | |
| 56 | Alfredo Velázquez | 3.182 | 2014-2026 | |
| 57 | Dean McNeil | 3.185 | 2023-2038 | |
| 58 | Manuel Hernández | 3.188 | 2023-2034 | |
| 59 | Manuel Ávila# | 3.195 | 2031-2039 | |
| 60 | Dean O'Monahan* | 3.196 | 2007-2022 | |
| 61 | Iwao Maruyama# | 3.197 | 2027-2038 | |
| 62 | Bryant Duncan | 3.211 | 2009-2024 | |
| 63 | Ju-hyung Park# | 3.222 | 2027-2038 | |
| 64 | Jim MacCowan | 3.225 | 2023-2038 | |
| 65 | Ernesto Molina | 3.226 | 2021-2035 | |
| 66 | Manuel López | 3.228 | 2030-2037 | |
| 67 | César Fuentes | 3.231 | 2022-2037 | |
| 68 | Jorge Medina | 3.237 | 2027-2038 | |
| 69 | Duane Moss# | 3.238 | 2031-2040 | |
| 69 | Armando Gallegos | 3.238 | 2009-2024 | |
| 71 | Melvin McNeal | 3.240 | 2024-2035 | |
| 72 | Marcos González | 3.242 | 2015-2028 | |
| 73 | Carl Ford# | 3.244 | 2030-2040 | |
| 73 | Chris Pate# | 3.244 | 2035-2040 | |
| 75 | Erik Watson | 3.246 | 2026-2038 | |
| 76 | José Cruz | 3.250 | 2007-2018 | |
| 77 | Felipe Lara | 3.251 | 2007-2012 | |
| 78 | Sang-ton Kun# | 3.257 | 2029-2040 | |
| 79 | Seon-chin Pak | 3.263 | 2019-2028 | |
| 80 | Roberto Cisneros# | 3.264 | 2030-2039 | |
| 80 | Kirby Gibson | 3.264 | 2007-2015 | |
| 82 | Fred Benjamin | 3.273 | 2014-2029 | |
| 83 | Volmer Buscher# | 3.287 | 2030-2040 | |
| 84 | Jorge Aguilar | 3.304 | 2007-2024 | |
| 85 | Juan Vargas# | 3.309 | 2033-2039 | |
| 85 | Pat Willis# | 3.309 | 2028-2038 | |
| 87 | Dave Barker | 3.310 | 2013-2021 | |
| 88 | Francisco Sútrez | 3.315 | 2026-2035 | |
| 88 | Chris Brown# | 3.315 | 2027-2040 | |
| 90 | John Turner | 3.323 | 2021-2037 | |
| 91 | Valentim Ornelas | 3.325 | 2022-2030 | |
| 92 | Takanobu Shirai | 3.328 | 2021-2036 | |
| 93 | Carmelo Lamberti# | 3.331 | 2033-2040 | |
| 94 | Brenden Clymo# | 3.335 | 2033-2040 | |
| 95 | José Fernández | 3.336 | 2027-2036 | |
| 96 | Armando Batista# | 3.341 | 2032-2040 | |
| 97 | Randy Zimmerman# | 3.347 | 2026-2039 | |
| 97 | Eduardo Romano | 3.347 | 2022-2032 | |
| 99 | Miguel Torres# | 3.350 | 2031-2038 | |
| 100 | Allen Cook | 3.358 | 2026-2035 |
