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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Jorge Ruíz# | 830 | 2025-2039 | |
| 2 | José Rosas | 456 | 2015-2030 | |
| 3 | Luis Cruz# | 443 | 2017-2039 | |
| 4 | Juan Jose Montoya# | 438 | 2024-2039 | |
| 5 | Enrico Vera# | 414 | 2019-2039 | |
| 6 | Carlos Gonzáles# | 368 | 2028-2039 | |
| 7 | Carlos Romero | 366 | 2017-2034 | |
| 8 | Francisco Martínez | 347 | 2028-2038 | |
| 9 | Orlando Rodríguez# | 346 | 2021-2039 | |
| 10 | José Hernández | 323 | 2020-2035 | |
| 11 | Jaime García | 273 | 2029-2035 | |
| 12 | Manny Cruz | 243 | 2007-2017 | |
| 13 | Roberto Lara# | 234 | 2016-2039 | |
| 14 | José Pérez# | 209 | 2024-2035 | |
| 15 | Luis Miguel Adron# | 207 | 2031-2039 | |
| 15 | Reynaldo Sánchez | 207 | 2016-2028 | |
| 17 | Jesús Franco | 203 | 2007-2026 | |
| 17 | José Valdéz# | 203 | 2023-2039 | |
| 19 | Jesús Reynoso# | 195 | 2024-2039 | |
| 20 | Salvador Reyes | 189 | 2007-2020 | |
| 21 | Marcos Disdier | 172 | 2007-2012 | |
| 22 | Anastasio Días | 168 | 2007-2026 | |
| 22 | Enrique Ortíz | 168 | 2007-2016 | |
| 24 | Ramiro Fonseca | 165 | 2028-2036 | |
| 25 | Enrique Hernández# | 164 | 2025-2039 | |
| 26 | Claudio Cardona# | 156 | 2026-2039 | |
| 27 | José Rea# | 155 | 2028-2039 | |
| 28 | Alfredo Reynoso | 150 | 2023-2033 | |
| 29 | Esteban Germán# | 149 | 2030-2039 | |
| 29 | Roberto Yánez# | 149 | 2030-2039 | |
| 31 | Vicente Sáenz# | 146 | 2029-2039 | |
| 31 | Arturo Torres | 146 | 2007-2016 | |
| 33 | Miguel Morales | 142 | 2007-2013 | |
| 34 | Roberto Ruíz | 141 | 2027-2036 | |
| 35 | Félix Luna# | 139 | 2029-2039 | |
| 36 | Raúl Padilla# | 138 | 2028-2039 | |
| 37 | Germán Barrera# | 136 | 2030-2039 | |
| 38 | Pablo Souza | 133 | 2017-2028 | |
| 39 | Manny Gonzáles# | 128 | 2028-2039 | |
| 39 | Mario Ortega# | 128 | 2030-2039 | |
| 41 | Juan Manuel# | 127 | 2027-2039 | |
| 42 | Carlos Colón | 125 | 2007-2012 | |
| 42 | Rafael Francisco# | 125 | 2023-2039 | |
| 42 | Juan Sánchez# | 125 | 2030-2039 | |
| 45 | José Alsina | 124 | 2007-2023 | |
| 45 | Carlos Álvarez# | 124 | 2030-2039 | |
| 47 | Sergio Morán | 122 | 2007-2020 | |
| 47 | Ramón Serna# | 122 | 2018-2039 | |
| 49 | Manuel Rincón# | 119 | 2030-2039 | |
| 50 | David Hidalgo | 118 | 2007-2017 | |
| 51 | Enrique Beltrán# | 117 | 2031-2039 | |
| 52 | Cristián Quiñones | 116 | 2010-2027 | |
| 52 | Miguel Soto | 116 | 2015-2026 | |
| 54 | Luis Guzmán# | 113 | 2029-2039 | |
| 55 | Roberto Ortíz | 110 | 2017-2027 | |
| 56 | Jesús Ramos# | 109 | 2029-2039 | |
| 57 | José Morán | 102 | 2014-2025 | |
| 58 | António González# | 101 | 2016-2039 | |
| 58 | José Pérez | 101 | 2007-2010 | |
| 60 | Jaime García | 98 | 2007-2011 | |
| 61 | Roberto Orralde# | 94 | 2030-2039 | |
| 62 | Diego Vásquez | 93 | 2007-2013 | |
| 63 | César Castillo | 92 | 2007-2011 | |
| 63 | Júlio Rangel# | 92 | 2030-2039 | |
| 65 | Jesús Suárez | 91 | 2011-2016 | |
| 66 | Domingo López | 90 | 2029-2035 | |
| 67 | Jorge Díaz# | 89 | 2030-2039 | |
| 68 | Armando Cruz# | 88 | 2032-2039 | |
| 68 | Gabriel Rocha | 88 | 2012-2016 | |
| 70 | Juan Manuel# | 87 | 2034-2039 | |
| 71 | Daniel Sutton Jr.# | 85 | 2029-2039 | |
| 72 | Luis Miguel Hernández | 84 | 2007-2016 | |
| 72 | Francisco Herrera# | 84 | 2030-2039 | |
| 74 | Francisco Montés# | 83 | 2030-2039 | |
| 75 | Jorge Coreto | 81 | 2007-2017 | |
| 75 | Javier González# | 81 | 2030-2039 | |
| 75 | Bartolo Muñóz | 81 | 2007-2016 | |
| 78 | Ángel Alvarado | 77 | 2007-2010 | |
| 78 | Francisco Martínez | 77 | 2007-2016 | |
| 78 | Emílio Torres# | 77 | 2017-2039 | |
| 81 | Roberto Torres# | 76 | 2031-2039 | |
| 82 | Lorenzo Ortíz# | 75 | 2034-2039 | |
| 83 | Tony Hernández# | 74 | 2025-2039 | |
| 84 | José Serrano | 73 | 2007-2014 | |
| 85 | António Mendoza | 72 | 2007-2011 | |
| 85 | Sandro Torres | 72 | 2026-2036 | |
| 85 | Andrés Vargas# | 72 | 2030-2039 | |
| 85 | Mario Vázquez# | 72 | 2027-2039 | |
| 89 | José Codne# | 70 | 2029-2039 | |
| 89 | Eduardo Romero# | 70 | 2026-2039 | |
| 91 | Sergio García | 67 | 2009-2017 | |
| 92 | Rafael Gonzáles | 66 | 2007-2010 | |
| 92 | Javier Madrid | 66 | 2007-2021 | |
| 92 | Tony Martínez | 66 | 2007-2014 | |
| 95 | César Jiménez# | 65 | 2029-2039 | |
| 95 | Ramón Nieto | 65 | 2007-2012 | |
| 95 | António Rivera# | 65 | 2034-2039 | |
| 98 | Jorge Alemán | 64 | 2007-2011 | |
| 98 | Cisco Mercado# | 64 | 2030-2039 | |
| 98 | Ángel Rivera# | 64 | 2035-2039 |
