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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Octávio Rivera# | 256 | 2022-2039 | |
| 2 | Héctor Pérez | 239 | 2011-2031 | |
| 3 | Raúl Canseco# | 207 | 2023-2039 | |
| 4 | Manny Flores# | 202 | 2027-2039 | |
| 4 | António Rodríguez# | 202 | 2027-2039 | |
| 6 | Manuel Arroyo | 198 | 2015-2036 | |
| 7 | Manuel Muñóz# | 191 | 2027-2039 | |
| 8 | Martín Silva | 189 | 2025-2039 | |
| 9 | Félix Villalobas# | 187 | 2024-2039 | |
| 10 | Raúl Pacheco | 177 | 2025-2038 | |
| 10 | José Vega# | 177 | 2023-2039 | |
| 12 | José Pérez# | 172 | 2028-2039 | |
| 13 | Pancho Gómez# | 170 | 2030-2039 | |
| 14 | Juan Castillo# | 169 | 2026-2039 | |
| 15 | Sergio López | 165 | 2016-2026 | |
| 15 | Ricardo Martínez | 165 | 2027-2034 | |
| 17 | Carlos Rivera# | 162 | 2029-2039 | |
| 18 | Jesús Muñóz# | 155 | 2026-2039 | |
| 19 | Tomás Costa | 153 | 2007-2021 | |
| 19 | Ricardo Martínez# | 153 | 2024-2039 | |
| 21 | Félix López# | 149 | 2027-2039 | |
| 21 | Javier Sousa | 149 | 2011-2021 | |
| 23 | Carlos Cosme# | 147 | 2029-2039 | |
| 24 | Pedro Garza | 146 | 2025-2034 | |
| 25 | Ramón Días# | 142 | 2030-2039 | |
| 26 | António Flores# | 141 | 2028-2039 | |
| 26 | Jesús Núñez | 141 | 2015-2026 | |
| 26 | Pedro Ramírez# | 141 | 2027-2039 | |
| 29 | Arturo García | 138 | 2007-2023 | |
| 30 | Francisco Aguilar# | 136 | 2032-2039 | |
| 30 | Juan Cardenas | 136 | 2012-2030 | |
| 32 | Carlos Domínguez# | 135 | 2027-2039 | |
| 32 | Rubén Mejía# | 135 | 2027-2039 | |
| 34 | Julián Alaniz# | 133 | 2029-2039 | |
| 34 | Jorge Ruíz | 133 | 2009-2029 | |
| 36 | Bernardo Sánchez# | 131 | 2030-2039 | |
| 37 | Carlos Flores# | 130 | 2030-2039 | |
| 37 | Pedro Reyes# | 130 | 2025-2039 | |
| 39 | José Campos# | 127 | 2030-2039 | |
| 40 | Rafael Diéguez# | 124 | 2025-2039 | |
| 40 | António Lima# | 124 | 2029-2039 | |
| 42 | António Soto# | 123 | 2030-2039 | |
| 43 | Ramiro Martínez# | 122 | 2027-2039 | |
| 43 | Rafael Ramírez | 122 | 2017-2030 | |
| 43 | Ramón Villalobos# | 122 | 2028-2039 | |
| 46 | Manny Rodríguez# | 120 | 2019-2039 | |
| 46 | Roberto Sánchez# | 120 | 2023-2039 | |
| 48 | Rodrigo Hernández# | 119 | 2031-2039 | |
| 49 | Roberto Cruz | 118 | 2023-2029 | |
| 50 | Manny Ríos# | 116 | 2030-2039 | |
| 51 | Juan Gamboa | 114 | 2022-2038 | |
| 51 | Alberto Guerra# | 114 | 2030-2039 | |
| 53 | Cipriano Baca | 112 | 2018-2027 | |
| 54 | Sergio Pinzón# | 111 | 2029-2039 | |
| 55 | Francisco Ramírez# | 110 | 2022-2039 | |
| 55 | Víctor Rodeco# | 110 | 2028-2039 | |
| 57 | Carlos López# | 108 | 2029-2039 | |
| 57 | Lúcio Saldaña# | 108 | 2023-2034 | |
| 59 | Arturo Acevedo# | 107 | 2030-2034 | |
| 59 | Félix Martínez | 107 | 2007-2015 | |
| 61 | Pedro Chávez | 106 | 2007-2023 | |
| 62 | Oliver Morales | 105 | 2021-2030 | |
| 63 | Israel Villarreal | 99 | 2007-2018 | |
| 64 | José Prieto# | 98 | 2030-2039 | |
| 65 | Manuel Ramírez | 96 | 2007-2014 | |
| 66 | César Meléndez# | 95 | 2034-2039 | |
| 66 | Víctor Meléndez# | 95 | 2031-2039 | |
| 66 | Jesús Sánchez# | 95 | 2030-2039 | |
| 66 | Ramón Torres# | 95 | 2029-2039 | |
| 70 | Cisco Salgado | 94 | 2007-2012 | |
| 70 | Armando Tapia | 94 | 2007-2012 | |
| 72 | Raúl Randín | 93 | 2007-2016 | |
| 72 | Júlio Torres | 93 | 2022-2028 | |
| 74 | Mario Mendoza | 92 | 2007-2017 | |
| 75 | David Bienavides# | 91 | 2031-2037 | |
| 76 | Juan Castro# | 90 | 2013-2039 | |
| 76 | Luis Ramos | 90 | 2011-2026 | |
| 78 | Juan Cora# | 89 | 2030-2039 | |
| 78 | Cristián Delanoval# | 89 | 2030-2039 | |
| 80 | Héctor Ordóñez# | 88 | 2026-2039 | |
| 80 | Eduardo Romano | 88 | 2011-2021 | |
| 82 | Roberto Alonaso# | 87 | 2030-2039 | |
| 82 | Martín Gómez# | 87 | 2028-2039 | |
| 82 | Pedro Ramírez | 87 | 2007-2011 | |
| 85 | Juan Rodríguez# | 86 | 2024-2039 | |
| 85 | César Soto | 86 | 2015-2030 | |
| 87 | Victor Hall | 85 | 2016-2021 | |
| 87 | Diego Rúbio | 85 | 2022-2030 | |
| 87 | José Vargas# | 85 | 2027-2039 | |
| 87 | Bernardo Vigil# | 85 | 2026-2039 | |
| 91 | Augusto Espinoza | 84 | 2007-2014 | |
| 91 | Alfonso Martínez | 84 | 2020-2025 | |
| 93 | Juan Barrón# | 82 | 2030-2039 | |
| 93 | Vincente Durán | 82 | 2019-2033 | |
| 93 | Salvador Martínez# | 82 | 2032-2039 | |
| 96 | Augusto Cervantes | 81 | 2016-2030 | |
| 96 | Arturo Luna# | 81 | 2029-2039 | |
| 96 | Júlio Ramos# | 81 | 2033-2039 | |
| 99 | Héctor Molina# | 80 | 2031-2039 | |
| 100 | Luis Farías# | 78 | 2030-2039 |
