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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Jesús Reynoso# | 195 | 2024-2039 | |
| 2 | Esteban Germán# | 149 | 2030-2039 | |
| 3 | José Alsina | 124 | 2007-2023 | |
| 4 | Sergio Morán | 122 | 2007-2020 | |
| 5 | Júlio Rangel# | 92 | 2030-2039 | |
| 6 | José Morán | 84 | 2014-2025 | |
| 7 | Ramiro Fonseca | 82 | 2028-2036 | |
| 8 | Javier González# | 81 | 2030-2039 | |
| 9 | Rafael Gonzáles | 66 | 2007-2010 | |
| 10 | Manuel Sánchez# | 63 | 2035-2039 | |
| 11 | Javier Cháves# | 52 | 2032-2039 | |
| 12 | Salvador Medrano | 49 | 2020-2024 | |
| 13 | José Santos# | 48 | 2027-2039 | |
| 14 | Pedro León# | 47 | 2029-2039 | |
| 14 | Alberto Serrano | 47 | 2019-2027 | |
| 16 | Rodrigo Mercado# | 44 | 2032-2039 | |
| 17 | Héctor García# | 33 | 2031-2039 | |
| 18 | Russ Huber | 27 | 2008-2008 | |
| 19 | Jack Hughes | 21 | 2008-2008 | |
| 20 | Jorge Hernández# | 20 | 2032-2039 | |
| 21 | Jorge Balderas# | 19 | 2031-2037 | |
| 21 | Rex Groves | 19 | 2008-2008 | |
| 23 | Francisco González# | 18 | 2037-2039 | |
| 23 | Jeffery Graham | 18 | 2008-2008 | |
| 25 | Gabriel Camacho | 17 | 2016-2027 | |
| 26 | Luis Navarro | 14 | 2010-2013 | |
| 26 | Carlos Rivera | 14 | 2007-2009 | |
| 26 | Juan Salazar# | 14 | 2025-2039 | |
| 29 | Octávio Díaz | 13 | 2013-2018 | |
| 30 | Alberto García# | 10 | 2037-2039 | |
| 30 | Iván Hernández# | 10 | 2031-2039 | |
| 30 | Gerald McKnight | 10 | 2008-2009 | |
| 30 | Jesús Ramírez# | 10 | 2030-2039 | |
| 34 | Ángel Durango# | 8 | 2035-2039 | |
| 34 | Gustavo Torres# | 8 | 2039-2039 | |
| 36 | David Corona# | 5 | 2032-2035 | |
| 36 | Cisco González# | 5 | 2032-2035 | |
| 36 | Juan Reyes# | 5 | 2038-2039 | |
| 36 | Luis Valentín# | 5 | 2037-2037 | |
| 40 | Nathan Clark | 4 | 2014-2014 | |
| 40 | Alfredo Cruz# | 4 | 2038-2039 | |
| 40 | Bartolo Martínez | 4 | 2010-2010 | |
| 40 | Katsunan Sakei | 4 | 2007-2007 | |
| 40 | Fernando Vázquez# | 4 | 2037-2038 | |
| 45 | Alonso Andrade# | 3 | 2033-2036 | |
| 45 | Pablo López# | 3 | 2032-2038 | |
| 45 | Jerry Miller | 3 | 2016-2017 | |
| 45 | Lorenzo Rangel# | 3 | 2037-2039 | |
| 45 | Jesús Valle# | 3 | 2033-2039 | |
| 45 | Ramón Vélez# | 3 | 2037-2039 | |
| 51 | Miguel Hernández# | 2 | 2038-2038 | |
| 51 | Ramiro Rodríguez# | 2 | 2037-2039 | |
| 51 | Ryosei Tanaka | 2 | 2013-2014 | |
| 51 | Hirotaka Toiguchi | 2 | 2007-2009 | |
| 55 | Richard Carney | 1 | 2014-2014 | |
| 55 | Julián Durán# | 1 | 2037-2038 | |
| 55 | Hideaki Ikeda | 1 | 2007-2007 | |
| 55 | Juan Machado | 1 | 2015-2015 | |
| 55 | Jesús Marroquín# | 1 | 2030-2039 | |
| 55 | Enrique Rodríguez# | 1 | 2034-2039 | |
| 55 | Ángel Rodríguez | 1 | 2010-2019 | |
| 62 | Anastasio Bojórquez | 0 | 2009-2010 | |
| 62 | Lorenzo Cabrera# | 0 | 2039-2039 | |
| 62 | Juan Díaz# | 0 | 2036-2036 | |
| 62 | António Encarnación | 0 | 2014-2014 | |
| 62 | Andrés Guardado# | 0 | 2037-2039 | |
| 62 | Matsudaira Horiuchi | 0 | 2008-2009 | |
| 62 | David Kellam | 0 | 2012-2012 | |
| 62 | Ramiro Lugo# | 0 | 2039-2039 | |
| 62 | Miguel Morales# | 0 | 2036-2036 | |
| 62 | Edgard Moralest# | 0 | 2038-2039 | |
| 62 | Santiago Ortíz# | 0 | 2038-2038 | |
| 62 | Jorge Velásquez# | 0 | 2030-2038 | |
| 62 | Nori Yamamoto | 0 | 2008-2009 |
