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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Ricardo Macías# | 1.867 | 2031-2039 | |
| 2 | Juan Romero | 2.382 | 2007-2026 | |
| 3 | Gabriel López# | 2.623 | 2030-2039 | |
| 4 | Carlos Macías | 2.658 | 2030-2037 | |
| 5 | Ismael López# | 2.760 | 2024-2039 | |
| 6 | Octávio Rivera | 2.771 | 2008-2027 | |
| 7 | José Morán# | 2.803 | 2021-2039 | |
| 8 | Juan Castro | 2.871 | 2012-2030 | |
| 9 | Paco Martínez# | 2.920 | 2026-2039 | |
| 10 | Miguel González# | 2.937 | 2024-2039 | |
| 11 | Dani Júlio# | 2.967 | 2034-2039 | |
| 12 | José Nieto | 2.984 | 2009-2018 | |
| 13 | Bartolo Jaimes# | 3.010 | 2028-2039 | |
| 14 | Bartolo Anaya# | 3.023 | 2030-2038 | |
| 15 | Mario García# | 3.027 | 2032-2039 | |
| 16 | Ramón Manuel# | 3.096 | 2024-2039 | |
| 17 | Sixto Castro# | 3.121 | 2033-2039 | |
| 18 | Carlos Ruíz | 3.162 | 2017-2025 | |
| 18 | Juan Silva | 3.162 | 2007-2013 | |
| 20 | Ignacio Filgueira# | 3.170 | 2025-2039 | |
| 21 | José Durango | 3.174 | 2011-2020 | |
| 22 | Roberto Gallardo# | 3.197 | 2028-2039 | |
| 23 | Fernando Cabrera# | 3.247 | 2029-2039 | |
| 24 | José Lozano | 3.255 | 2018-2037 | |
| 25 | Héctor Galló | 3.277 | 2014-2023 | |
| 26 | Alonso Gutiérrez# | 3.295 | 2029-2039 | |
| 27 | Carlos Amador# | 3.325 | 2026-2039 | |
| 28 | David Mendoza# | 3.331 | 2030-2039 | |
| 29 | Jesús López# | 3.339 | 2017-2039 | |
| 30 | Fernando Moreno# | 3.402 | 2030-2039 | |
| 31 | Luis Pérez | 3.446 | 2007-2011 | |
| 32 | Manuel García# | 3.461 | 2032-2039 | |
| 33 | Robinson Flores# | 3.463 | 2026-2039 | |
| 34 | Martín Ramírez | 3.501 | 2014-2036 | |
| 35 | Mario García | 3.521 | 2018-2033 | |
| 36 | Orlando Ruíz | 3.590 | 2007-2011 | |
| 37 | Domingo Rodríguez | 3.636 | 2013-2021 | |
| 38 | Iván Chávez# | 3.654 | 2030-2039 | |
| 39 | José Castillo | 3.699 | 2015-2038 | |
| 40 | Juan Sorondo | 3.708 | 2018-2032 | |
| 41 | Cristo Costello# | 3.776 | 2029-2038 | |
| 42 | Alberto Guerra | 3.813 | 2010-2020 | |
| 43 | Alberto Galván | 3.824 | 2007-2021 | |
| 44 | Carlos Peña | 3.875 | 2011-2029 | |
| 45 | Fernando Vega# | 3.876 | 2028-2039 | |
| 46 | Tetsuo Okazaki | 4.146 | 2008-2017 | |
| 47 | Cristo Román | 4.864 | 2009-2016 |
