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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saito, Suezo | RF | Hoboken Crooners | 24 | 02/03/2016 | Takaoka | JPN | Left | Left | 6' 5" | 205 lbs | - |
| Sakei, Shumei | RP | Calexico Reins | 20 | 10/24/2019 | Kawasaki | JPN | Right | Right | 6' 7" | 195 lbs | - |
| Sakurai, Sotatsu | SP | Govan Shipbuilders | 22 | 12/20/2017 | Yokohama | JPN | Right | Right | 6' 2" | 195 lbs | - |
| Salinas, Francisco | SS | Escondido Stone Brews | 23 | 12/16/2016 | Masaya | NCA | Right | Right | 6' 1" | 190 lbs | - |
| Samurakami, Takafumi | 2B | Ensenada Las Brujas Malvadas | 19 | 01/05/2021 | Fujieda | JPN | Left | Right | 6' 3" | 170 lbs | - |
| Sanders, Paul | SP | Rosarito Monjas del Vuelo | 25 | 01/26/2015 | Carpentersville | USA | Switch | Right | 6' 0" | 180 lbs | - |
| Sanders, Randy | 1B | Mexicali Shmoes | 24 | 09/23/2015 | Austin | USA | Right | Right | 6' 1" | 175 lbs | - |
| Sandoval, Ramón | CL | Chula Vista Chargers | 22 | 10/17/2017 | Ferry Pass | USA | Right | Right | 5' 10" | 165 lbs | - |
| Sano, Hideo | LF | Hoboken Crooners | 21 | 03/07/2019 | Fukushima | JPN | Right | Left | 6' 2" | 180 lbs | - |
| Santopadre, Ruggieri | DH | Jackson Hole Twin Titans | 23 | 05/27/2016 | Rome | ITA | Right | Right | 6' 2" | 200 lbs | - |
| Sasaki, Yosuke | C | Marduk Nerv | 22 | 05/11/2017 | Tomiya | JPN | Right | Right | 5' 10" | 185 lbs | - |
| Sastre, Bartholomeu | 3B | Birmingham Bears | 23 | 10/13/2016 | Nova Friburgo | BRA | Right | Right | 6' 2" | 185 lbs | - |
| Sato, Masaharu | 2B | Fort Wayne Pioneers | 24 | 08/16/2015 | Chino | JPN | Right | Right | 6' 1" | 195 lbs | - |
| Satterfield, Greg | RP | Free Agent | 20 | 02/07/2020 | Warner Robins | USA | Right | Right | 6' 2" | 165 lbs | - |
| Schaefer, Chris | 3B | Tijuana Saguaros | 22 | 06/10/2017 | Garden Grove | USA | Right | Right | 6' 1" | 195 lbs | - |
| Scrovegni, Maxime | SP | Tijuana Saguaros | 20 | 04/29/2019 | Córdoba | ARG | Right | Right | 6' 7" | 200 lbs | - |
| Seaward, Roy | C | Rapid City Rushmores | 24 | 12/20/2015 | Pudsey | ENG | Right | Right | 6' 2" | 200 lbs | - |
| Segura, Marcos | SP | San Luis Rio Colorado Rapidos Blancos | 24 | 01/09/2016 | Nagua | DOM | Right | Right | 6' 2" | 200 lbs | - |
| Sekine, Toru | 3B | Jackson Hole Twin Titans | 23 | 10/02/2016 | Kochi | JPN | Switch | Right | 6' 1" | 195 lbs | - |
| Serafim, Vítor | SP | Mexicali Shmoes | 24 | 06/12/2015 | Aracaju | BRA | Left | Left | 6' 1" | 195 lbs | - |
| Serrano, Ramón | RP | Free Agent | 22 | 04/13/2018 | Diego de Almagro | CHI | Right | Right | 6' 2" | 185 lbs | - |
| Sharp, Curt | 1B | Fort Wayne Pioneers | 22 | 11/25/2017 | Melbourne | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sherman, Dave | SP | Fort Wayne Pioneers | 20 | 06/04/2019 | Lacombe | CAN | Switch | Right | 6' 0" | 180 lbs | - |
| Shimada, Mitsuharu | RP | Jackson Hole Twin Titans | 23 | 06/15/2016 | Kurume | JPN | Switch | Right | 6' 0" | 190 lbs | - |
| Shimizu, Tatsukichi | CF | Free Agent | 25 | 01/21/2015 | Funabashi | JPN | Right | Right | 6' 4" | 200 lbs | - |
| Shipway, Josh | 3B | Mexicali Shmoes | 24 | 03/08/2016 | Lowestoft | ENG | Left | Right | 6' 0" | 200 lbs | - |
| Shirley, Denny | 1B | Gakidou Onryou | 24 | 12/28/2015 | Augusta-Richmond County | USA | Left | Right | 6' 2" | 195 lbs | - |
| Shiroi, Koki | RP | Nagano Olympians | 22 | 09/11/2017 | Kochi | JPN | Right | Right | 6' 1" | 185 lbs | - |
| Shiroi, Ryosei | RP | Ensenada Las Brujas Malvadas | 19 | 08/15/2020 | Hitachinaka | JPN | Right | Right | 5' 9" | 165 lbs | - |
| Shui, Gin-fan | RF | Gakidou Onryou | 24 | 03/01/2016 | Zhenjiang | CHN | Left | Left | 6' 2" | 195 lbs | - |
| Sihâbeddîn, Shâhrukh | RP | Tijuana Saguaros | 21 | 03/05/2019 | Meschede | GER | Left | Left | 6' 2" | 185 lbs | - |
| Silva, Carlos | SS | Ensenada Las Brujas Malvadas | 23 | 03/19/2017 | San José | CRC | Right | Right | 6' 1" | 185 lbs | - |
| Silva, Raúl | 2B | Nagano Olympians | 22 | 09/11/2017 | Cúcuta | COL | Right | Right | 6' 0" | 195 lbs | - |
| Silva, Ricardo | SS | Kingston Suns | 23 | 08/06/2016 | El Llano | MEX | Right | Right | 6' 3" | 200 lbs | - |
| Simbolon, Mulia | SP | Middle Bass Vintners | 20 | 07/16/2019 | Pacet | IDN | Right | Right | 6' 8" | 200 lbs | - |
| Simpson, Joe | SP | Escondido Stone Brews | 24 | 01/09/2016 | Pike Creek | USA | Left | Right | 5' 11" | 180 lbs | - |
| Sims, Sandy | SS | Gakidou Onryou | 24 | 10/29/2015 | Windsor Heights | USA | Left | Right | 6' 2" | 195 lbs | - |
| Sin, Keun-ho | SP | Rapid City Rushmores | 23 | 01/13/2017 | Pusan | KOR | Right | Right | 6' 0" | 190 lbs | - |
| Siu, Wu-jiang | LF | Takaoka Shiko | 23 | 12/21/2016 | Xinxiang | CHN | Right | Right | 6' 1" | 200 lbs | $560,000 |
| Smith, Chet | SS | Utrecht Scholars | 23 | 12/03/2016 | Albuquerque | USA | Switch | Right | 6' 0" | 190 lbs | - |
| Smith, John | RP | Escondido Stone Brews | 21 | 06/09/2018 | Saint Paul | USA | Right | Right | 6' 1" | 175 lbs | - |
| Smith, Zach | RF | Nassau Vulcans | 22 | 02/24/2018 | Henderson | USA | Right | Right | 6' 3" | 200 lbs | - |
| So, Cheong-u | SP | Rosarito Monjas del Vuelo | 24 | 12/30/2015 | Wabu | KOR | Right | Right | 6' 3" | 195 lbs | - |
| Sosa, Gonzalo | LF | Alexandria Macedonians | 24 | 12/21/2015 | Albuquerque | USA | Right | Right | 6' 2" | 195 lbs | - |
| Sosa, José | 2B | Drumright Tornadoes | 22 | 09/11/2017 | Cartagena | COL | Left | Right | 5' 11" | 170 lbs | - |
| Soto, Tomás | CL | Birmingham Bears | 22 | 09/13/2017 | South Daytona | USA | Right | Right | 6' 1" | 185 lbs | - |
| Souder, Jake | SP | Escondido Stone Brews | 22 | 06/18/2017 | Newark | USA | Left | Right | 6' 1" | 170 lbs | - |
| Spinks, Stephen | LF | Nagano Olympians | 21 | 12/19/2018 | Aldergrove | CAN | Left | Left | 6' 2" | 185 lbs | - |
| Sproule, Alan | LF | Ensenada Las Brujas Malvadas | 23 | 09/17/2016 | Port Lincoln | AUS | Left | Right | 6' 1" | 200 lbs | - |
| Stephens, Howard | RF | Nagano Olympians | 20 | 11/11/2019 | Houston | USA | Right | Right | 6' 6" | 205 lbs | - |
| Stewart, Norm | 1B | Govan Shipbuilders | 24 | 06/02/2015 | Canberra | AUS | Right | Right | 6' 0" | 200 lbs | - |
| Sui, Qi-chen | C | Alexandria Macedonians | 20 | 05/06/2019 | Xinzhou | CHN | Right | Right | 6' 2" | 200 lbs | - |
| Sumita, Tetsuhiko | SP | Tijuana Saguaros | 21 | 08/24/2018 | Kitakyushu | JPN | Left | Left | 6' 2" | 195 lbs | - |
| Sun, Gui | SP | San Luis Rio Colorado Rapidos Blancos | 24 | 09/23/2015 | Shanghai | CHN | Right | Right | 6' 2" | 190 lbs | - |
| Surtees, Noah | SP | Hoboken Crooners | 22 | 06/25/2017 | London | ENG | Right | Right | 6' 2" | 175 lbs | - |
| Sutton, Terry | RF | Rosarito Monjas del Vuelo | 21 | 05/25/2018 | Vancouver | CAN | Left | Left | 6' 2" | 180 lbs | - |
| Suzuki, Hidekazu | RP | Mexicali Shmoes | 22 | 05/14/2017 | Aomori | JPN | Right | Right | 6' 3" | 200 lbs | - |
| Suzuki, Kamatari | LF | Jackson Hole Twin Titans | 23 | 11/07/2016 | Shiogama | JPN | Switch | Right | 6' 0" | 190 lbs | - |
| Suárez, Lúcio | SP | Rosarito Monjas del Vuelo | 23 | 12/19/2016 | Panama | PAN | Switch | Right | 6' 4" | 200 lbs | - |
| Sánchez, Gerardo | CF | Tijuana Saguaros | 22 | 06/25/2017 | Carmen de Patagones | ARG | Switch | Right | 6' 1" | 185 lbs | - |
| Sánchez, Jesús | 2B | Rapid City Rushmores | 21 | 06/17/2018 | San Juan de la Maguana | DOM | Right | Right | 6' 1" | 185 lbs | - |
| Sánchez, Jesús | C | Govan Shipbuilders | 22 | 11/17/2017 | Naranjo | CRC | Right | Right | 6' 3" | 200 lbs | - |
| Sánchez, José | SP | Cheyenne Frontier | 21 | 10/22/2018 | Chinchina | COL | Left | Left | 6' 3" | 190 lbs | - |
| Sánchez, Lorenzo | SP | Nagano Olympians | 21 | 08/05/2018 | Tepeapulco | MEX | Right | Right | 6' 2" | 185 lbs | - |
| Sánchez, Máximo | 2B | Magami Ako | 22 | 09/27/2017 | Minneapolis | USA | Right | Right | 6' 1" | 185 lbs | $560,000 |
| Sánchez, Paco | 3B | Free Agent | 25 | 07/14/2014 | Soyapango | SLV | Right | Right | 6' 2" | 200 lbs | - |
| Sánchez, Pepe | SP | Free Agent | 25 | 10/01/2014 | El Limón | VEN | Switch | Right | 6' 0" | 180 lbs | - |
| Sánchez, Ramón | RP | Calexico Reins | 24 | 04/21/2016 | Philadelphia | USA | Right | Right | 5' 10" | 180 lbs | - |
